This hidden gem boasts old-town ambiance and many cultural and historic sites. Safety Harbor’s most famous destination is the Safety Harbor Resort and Spa. The 2,000-year-old mineral spring running beneath the resort was once enjoyed by local Indian tribes. Spanish explorer Hernando de Soto mistook the spring for the “Fountain of Youth” when he came ashore in 1539. Downtown Safety Harbor is home to specialty shops, galleries and restaurants along Main Street. A favorite destination for residents and visitors alike is the pier, which offers a prime opportunity to glimpse marine life.