Lewis and Clark walked this land more than 200 years ago, so, it only seems right to nosh on the eclectic cuisine at Lewis & Clark’s American Restaurant & Public House. Trailhead Brewing Co. is another good option—among many—serving a seriously upgraded sports bar menu and its line of house-brewed craft beers.
Brick-paved South Main Street is lined with more than 100 browse-worthy gift, gourmet and accessory stores, including Bathhouse Soapery and Caldarium, Siostra Polish Pottery and Gifts and Joys Collective Market, a rambling emporium with a little bit of everything.
History is abundant on South Main Street. Check out the First Missouri State Capitol State Historic Site, where the fledgling legislature first met from 1821 to 1826; and the Lewis & Clark Boat House and Museum, which houses replica Corps of Discovery boats, artifacts and exhibits.
Go gaming at Ameristar Casino Resort Spa St. Charles, just a few blocks off the South Main Historic District, or rent a bike at the Bike Stop Café and explore the nearby Katy Trail, which follows the Missouri River on the way to Missouri wine country.